Hair disorders may considerably impact the social and psychological well-being of\nan individual. Recent advances in the understanding the biology of hair have encouraged the\nresearch and development of novel and safer natural hair growth agents. In this context, we have\npreviously demonstratedâ??at both preclinical and clinical levelâ??that an Annurca apple-based dietary\nsupplement (AMS), acting as a nutraceutical, is endowed with an intense hair-inductive activity\n(trichogenicity), at once increasing hair tropism and keratin content. Herein, in the framework of\npreclinical investigations, new experiments in primary human models of follicular keratinocytes and\ndermal papilla cells have been performed to give an insight around AMS biological effects on specific\nhair keratins expression. As well as confirming the biocompatibility and the antioxidant proprieties\nof our nutraceutical formulation, we have proven an engagement of trichokeratins production\nunderlying its biological effects on human follicular cells. Annurca apples are particularly rich in\noligomeric procyanidins, natural polyphenols belonging to the broader class of bioflavonoids believed\nto exert many beneficial health effects. To our knowledge, none of the current available remedies for\nhair loss has hitherto shown to stimulate the production of hair keratins so clearly.
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